DIMENSIONS OF CHILDHOOD TRAUMA AND THEIR DIRECT AND INDIRECT LINKS TO PTSD, IMPAIRED CONTROL OVER DRINKING, AND ALCOHOL-RELATED-PROBLEMS

Dimensions of childhood trauma and their direct and indirect links to PTSD, impaired control over drinking, and alcohol-related-problems

Introduction: Post-Traumatic Stress Disorder (PTSD) develops after experiencing events that evoke fear, helplessness, or horror.The Hyperarousablity Hypothesis suggests that those with PTSD may drink more to dampen physiological reactivity.We examined the direct and indirect relationships between childhood trauma (e.g., physical-neglect, emotional-

read more

Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings.

Translation of radiomics into the clinic may require a more comprehensive understanding of the underlying morphologic tissue characteristics they reflect.In the context of prostate cancer (PCa), some studies have correlated gross histological measurements of gland lumen, epithelium, and nuclei with disease appearance on MRI.Quantitative histomorpho

read more

Reform of Life Imprisonment in Lithuania

This article discusses the 2019 reform of criminal laws, providing for the possibility of releasing persons sentenced to life Left Pier imprisonment.The legislator, establishing the model of punishment substitution instead of parole, chose a sufficiently strict regulation, and although he declared otherwise, he did not really dare to go beyond puni

read more

Preclinical Studies Comparing Efficacy and Toxicity of DNA Repair Inhibitors, Olaparib, and AsiDNA, in the Treatment of Carboplatin-Resistant Tumors

Purpose: Carboplatin is used to treat many cancers, but occurrence of drug resistance and its high toxicity remain a clinical hurdle limiting its efficacy.We compared the efficacy and toxicity of DNA repair inhibitors olaparib or AsiDNA administered alone or in combination with carboplatin.Olaparib acts by inhibiting PARP-dependent repair pathways

read more